Analytical Chemistry

Trace Organics

In analytical chemistry, the detection and quantification of trace organics are essential for various applications, including environmental monitoring and quality control.The quality of water used in sample preparation and analyses is crucial to ensure the accuracy and sensitivity of trace organic determinations. High-purity water is vital to prevent interference and maintain the integrity of chromatographic and spectroscopic analyses.

What Is The Impact Of Water On Trace Organics?

Water quality significantly impacts the reliability of trace organic analyses. Impurities in water can introduce background signals, affect chromatographic peak shapes, and compromise the accuracy of trace organic determinations, leading to unreliable results.

What Types Of Contaminants In Water Can Affect Trace Organic Analysis?

Water impurities that can impact trace organic analysis include:

Ionic Contaminants

Impact:

Elevated levels of ions can interfere with the detection of trace organics.

Effect:

Excess ions may contribute to baseline noise, affecting the sensitivity of detectors. In gas chromatography-mass spectrometry (GC-MS), for example, interference from ions can compromise the accuracy of trace organic identifications.

Organic Contaminants

Impact:

The presence of unintended organic compounds can interfere with the analysis of trace organics.

Effect:

In liquid chromatography-mass spectrometry (LC-MS), unintended organics may contribute to background signals, affecting the reliability of trace organic identifications. Matrix effects from organics can lead to inaccuracies in
quantification.

Particulates

Impact:

Presence of particulate matter in samples can introduce variability in trace organic analyses.

Effect:

Particulates may cause column contamination or affect detector performance, leading to fluctuations in signal intensity. This interference can compromise the precision of trace organic analyses.

Water Measurement Requirements for Trace Organics

In applications focused on detecting trace organics, maintaining a high level of water purity is crucial to prevent interference and ensure accurate analysis. The presence of organic impurities in water can introduce unwanted signals and affect the specificity of assays. For trace organics detection, the use of water with low total organic carbon (TOC) is essential, and apyrogenic, Type I ultrapure water is often recommended.

Water Quality Standards According to Industry Guidelines:

Method

Routine Trace Organic

Resistivity (MΩ.cm)*

TOC (ppb)

<50

Filter (μm)

<0.2

Bacteria (CFU/ml)

Endotoxins (EU/ml)

Nucleases

Method

High-Sensitivity Analysis

Resistivity (MΩ.cm)*

>18

TOC (ppb)

<10

Filter (μm)

<0.2

Bacteria (CFU/ml)

Endotoxins (EU/ml)

<0.002

Nucleases

Not detected

Method

Resistivity (MΩ.cm)*

TOC (ppb)

Filter (μm)

Bacteria (CFU/ml)

Endotoxins (EU/ml)

Nucleases

Routine Trace
Organic

<50

<0.2

High-Sensitivity
Analysis

>18

<10

<0.2

<0.002

Not detected

Adhering to these water quality standards is crucial for achieving accurate and reproducible results in trace organic analyses. Type I water is recommended for applications requiring the highest level of sensitivity, while Type II water may be suitable for routine analyses.

NOTES:

If removal of finer particulates (< 0.05 micron) is required, consider upgrading to CLS-5400 series systems.
Applications requiring Endotoxin filtration should purchase a CLF-5000-02E Endotoxin removal final filter.

CLS-3200

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CLïR 3200 High Purity Lab Water System with UV Oxidation

25.25

⅜" O.D. Tubing

120V/60Hz

> 18 MΩ/cm

< 10 CFU / ml

< 1ppb

< 5 ppb

Countertop, Wall Mount

Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics

Analytical Chemistry

CLS-5200-R-1-TOC

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CLïR 5200 Ultrapure Lab Water System with TOC Monitoring & UV Oxidation (Remote 120V)

14.4

21.6

14.7

⅜" O.D. Tubing

120V/60Hz

> 18 MΩ/cm

< 1 CFU/ml

< 1ppb

< 5 ppb

2.5

Wall Mount, Remote Dispense

Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics

Analytical Chemistry

CLS-5200-R-2-TOC

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CLïR 5200 Ultrapure Lab Water System with TOC & UV Oxidation (Remote 220V)

14.4

21.6

14.7

⅜" O.D. Tubing

220V/50Hz

> 18 MΩ/cm

< 1 CFU/ml

< 1ppb

< 5 ppb

2.5

Wall Mount, Remote Dispense

Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics

Analytical Chemistry

CLS-5200-S-1-TOC

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Download Spec Sheet

CLïR 5200 Ultrapure Lab Water System with TOC Monitor & UV Oxidation (Standard 120V)

14.4

21.6

14.7

½" O.D. Tubing

120V/60Hz

> 18 MΩ/cm

< 1 CFU/ml

< 1ppb

< 5 ppb

2.5

Countertop

Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics

Analytical Chemistry

System

Label

System Depth (in)

System Height (in)

System Width (in)

Dry Weight (lbs)

Inlet Connection

System Voltage

TOC Monitoring

0.05μ Ultrafiltration

Ultraviolet Oxidation

Effluent Purity

Effluent Microorganisms

Effluent Sodium

Effluent Chlorides

Effluent TOC

System Maximum
Output (lpm)

Volumetric Presets

Mounting

Laboratory Applications

CAtegory

CLS-3200

Get a quote

Download Spec Sheet

CLïR 3200 High Purity Lab Water System with UV Oxidation

25.25

⅜" O.D. Tubing

120V/60Hz

> 18 MΩ/cm

< 10 CFU / ml

< 1ppb

< 5 ppb

Countertop, Wall Mount

Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics

Analytical Chemistry

CLS-5200-R-1-TOC

Get a quote

Download Spec Sheet

CLïR 5200 Ultrapure Lab Water System with TOC Monitoring & UV Oxidation (Remote 120V)

14.4

21.6

14.7

⅜" O.D. Tubing

120V/60Hz

> 18 MΩ/cm

< 1 CFU/ml

< 1ppb

< 5 ppb

2.5

Wall Mount, Remote Dispense

Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics

Analytical Chemistry

CLS-5200-R-2-TOC

Get a quote

Download Spec Sheet

CLïR 5200 Ultrapure Lab Water System with TOC & UV Oxidation (Remote 220V)

14.4

21.6

14.7

⅜" O.D. Tubing

220V/50Hz

> 18 MΩ/cm

< 1 CFU/ml

< 1ppb

< 5 ppb

2.5

Wall Mount, Remote Dispense

Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics

Analytical Chemistry

CLS-5200-S-1-TOC

Get a quote

Download Spec Sheet

CLïR 5200 Ultrapure Lab Water System with TOC Monitor & UV Oxidation (Standard 120V)

14.4

21.6

14.7

½" O.D. Tubing

120V/60Hz

> 18 MΩ/cm

< 1 CFU/ml

< 1ppb

< 5 ppb

2.5

Countertop

Electrochemistry, Gas Chromatography Mass Spectrometry (GC/MS), High Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Trace Organics

Analytical Chemistry

The difference is CLïR.

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Applications

Analytical Chemistry

Trace Organics

What Is The Impact Of Water On Trace Organics?

Ionic Contaminants

Organic Contaminants

Particulates

Water Measurement Requirements for Trace Organics

Method

Resistivity (MΩ.cm)*

TOC (ppb)

Filter (μm)

Bacteria (CFU/ml)

Endotoxins (EU/ml)

Nucleases

Method

Resistivity (MΩ.cm)*

TOC (ppb)

Filter (μm)

Bacteria (CFU/ml)

Endotoxins (EU/ml)

Nucleases

System

Label

System Depth (in)

System Height (in)

System Width (in)

Dry Weight (lbs)

Inlet Connection

System Voltage

TOC Monitoring

0.05μ Ultrafiltration

Ultraviolet Oxydation

Effluent Purity

Effluent Microorganisms

Effluent Sodium

Effluent Chloride

Effluent TOC

System MaximumOutput (lpm)

Volumetric Presets

Mounting

Laboratory Applications

CAtegory

System

Label

System Depth (in)

System Height (in)

System Width (in)

Dry Weight (lbs)

Inlet Connection

System Voltage

TOC Monitoring

0.05μ Ultrafiltration

Ultraviolet Oxydation

Effluent Purity

Effluent Microorganisms

Effluent Sodium

Effluent Chloride

Effluent TOC

System MaximumOutput (lpm)

Volumetric Presets

Mounting

Laboratory Applications

CAtegory

System

Label

System Depth (in)

System Height (in)

System Width (in)

Dry Weight (lbs)

Inlet Connection

System Voltage

TOC Monitoring

0.05μ Ultrafiltration

Ultraviolet Oxydation

Effluent Purity

Effluent Microorganisms

Effluent Sodium

Effluent Chloride

Effluent TOC

System Maximum
Output (lpm)

System Maximum
Output (lpm)

System Maximum
Output (lpm)

System Maximum
Output (lpm)

System Maximum
Output (lpm)

System Maximum
Output (lpm)